mysql error: Error: 23 - Out of resources when opening file

[Nathan]

My server has a site that's getting a lot of traffic lately and I'm seeing some mysql errors coming up in the IP.Board logs.  It says it's an error with mysql not the software.

Anyone know how to fix the error:
Error: 23 - Out of resources when opening file

[Nathan]

I found some people saying to open:
/etc/security/limits.conf

and add:
mysql soft nofile 24000
mysql hard nofile 32000

Any issues with doing this?